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Commensal Organisms Can Protect Against Pathogenic Bacteria

Recent studies published in Science Immunology and Science have shown how a commensal intestinal bacterium produces an enzyme that can help protect against pathogenic bacteria.

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The Causes of Crohn’s Disease

According to experts, Crohn’s disease is developed through a combination of these risk factors: family history, immune system disorders and environmental factors.

Experts explained that Crohn’s disease is classified as an autoimmune disorder – a condition in which the body’s defense mechanism against harmful microbes or human pathogens has gone awry and begins to attack the body and organs. It is to be noted that there are microorganisms that are helpful in certain processes like digestion. Ideally, the immune system needs to leave it alone. But with Crohn’s disease, an autoimmune condition, the immune system will attack the “friendly” bacteria as well as surrounding cells.

The immune system’s improper reaction is what causes the inflammation. Attacking the “friendly” bacteria and the organs and cells, this inflammatory response will not cease any time soon. In the case of Crohn’s disease, this chronic adverse reaction will result in ulcers or damage to the intestines.

Family history also contributes to the development of Crohn’s disease. People who have parents or siblings with inflammatory bowel disorders like Crohn’s disease are susceptible to developing the condition. Around 10 percent to 20 percent of individuals diagnosed with the disease have at least one family member who has the condition. In addition, Caucasians and people of Jewish descent are more likely to get Crohn’s disease.

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